Proinflammatory Phenotype of Perivascular Adipocytes
نویسندگان
چکیده
منابع مشابه
Proinflammatory phenotype of perivascular adipocytes.
Perivascular adipose tissue (PVAT) directly abuts the lamina adventitia of conduit arteries and actively communicates with the vessel wall to regulate vascular function and inflammation. Mounting evidence suggests that the biological activities of PVAT are governed by perivascular adipocytes, a unique class of adipocyte with distinct molecular and phenotypic characteristics. Perivascular adipoc...
متن کاملProinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding.
Adipose tissue depots originate from distinct precursor cells, are functionally diverse, and modulate disease processes in a depot-specific manner. However, the functional properties of perivascular adipocytes, and their influence on disease of the blood vessel wall, remain to be determined. We show that human coronary perivascular adipocytes exhibit a reduced state of adipocytic differentiatio...
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Adipose tissue depots originate from distinct precursor cells, are functionally diverse, and modulate disease processes in a depot-specific manner. However, the functional properties of perivascular adipocytes, and their influence on disease of the blood vessel wall, remain to be determined. We show that human coronary perivascular adipocytes exhibit a reduced state of adipocytic differentiatio...
متن کاملIs there a pathophysiological role for perivascular adipocytes?
IN THIS ISSUE of American Journal of Physiology-Heart and Circulatory Physiology, Barandier et al. (1) describe that conditioned medium of cultured murine adipocytes (3T3-L1 cells) or rat perivascular adipose tissue stimulates human vascular smooth muscle cell proliferation. The growth factor(s) responsible are secreted by mature adipocytes but not by preadipocytes, are hydrosoluble proteins wi...
متن کاملDivergent phenotype of rat thoracic and abdominal perivascular adipose tissues.
Perivascular adipose tissue (PVAT) is implicated as a source of proatherogenic cytokines. Phenotypic differences in local PVAT depots may contribute to differences in disease susceptibility among arteries and even regions within an artery. It has been proposed that PVAT around the abdominal and thoracic aorta shares characteristics of white and brown adipose tissue (BAT), respectively; however,...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2014
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.114.303030